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COMPOSITION FOR PREVENTING AND TREATING TAUOPATHIES
Publication number: 20220313620
Abstract: This invention relates to the delivery of a composition, preferably a pharmaceutical composition, comprising D-pinitol, D-Chiro inositol or myo-inositol or any pharmaceutically acceptable salt thereof, for use in the treatment or prevention of disorders, diseases or conditions responsive to the stimulation of the ghrelin receptor in a subject in need thereof.
Type: Application
Filed: September 9, 2020
Publication date: October 6, 2022
Inventors: Fernando RODRIGUEZ DE FONSECA, Juan Antonio NAVARRO GALERA, Elena BAIXERAS LLANO, Juan Manuel DECARA DEL OLMO, Dina MEDINA VERA, Antonio Jesús LÓPEZ GAMBERO, Juan SUAREZ PEREZ, Carlos SANJUAN MERINO, Cristina ROSELL DEL VALLE, Francisco Javier PAVÓN MORÓN
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METHOD FOR PREDICTING OUTCOME OF CANCER IN A SUBJECT
Publication number: 20150087539
Abstract: The invention relates to a method for predicting the outcome of a subject suffering from cancer, based on the copy number of the CHKA gene in a sample from said subject. The invention also relates to a BAC composition and a method for detecting the number of copies of the CHKA gene.
Type: Application
Filed: July 13, 2012
Publication date: March 26, 2015
Applicant: TRASLATIONAL CANCER DRUGS PHARMA, S.L.
Inventor: Juan Carlos Lacal Sanjuan
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Derivatives of pyridine and quinoline
Publication number: 20070185170
Abstract: The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors and parasitic diseases or diseases produced by viruses and fungi in animals, including human beings; as well as to a method for preparing the compounds of the invention and certain intermediates of said method.
Type: Application
Filed: January 11, 2005
Publication date: August 9, 2007
Inventors: Juan Carlos Lacal Sanjuan, Joaquin Rosa, Miguel Mezo, Antonio Ubeda
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PYRIDINIUM AND QUINOLINIUM DERIVATIVES
Publication number: 20110178124
Abstract: The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors and parasitic diseases or diseases produced by viruses and fungi in animals, including human beings; as well as to a method for preparing the compounds of the invention and certain intermediates of said method.
Type: Application
Filed: August 13, 2010
Publication date: July 21, 2011
Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, UNIVERSIDAD DE GRANADA
Inventors: Juan Carlos Lacal Sanjuán, Joaquin Campos Rosa, Miguel Ángel Gallo Meza, Antonio Espinosa Ubeda
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Pyridinium and quinolinium derivatives
Patent number: 8586613
Abstract: The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors and parasitic diseases or diseases produced by viruses and fungi in animals, including human beings; as well as to a method for preparing the compounds of the invention and certain intermediates of said method.
Type: Grant
Filed: August 13, 2010
Date of Patent: November 19, 2013
Assignees: Universidad de Granada, Consejo Superior de Investigaciones Cientificas
Inventors: Juan Carlos Lacal Sanjuán, Joaquin Campos Rosa, Miguel Ángel Gallo Meza, Antonio Espinosa Ubeda
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METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Publication number: 20150297576
Abstract: The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent or a death receptor ligand and uses thereof for the treatment of cancer.
Type: Application
Filed: January 12, 2015
Publication date: October 22, 2015
Inventors: Ana Ramírez De Molina, Lordes Garcia Oroz, Juan Carlos Lacal Sanjuan
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Derivatives of pyridine and quinoline
Patent number: 7781458
Abstract: The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors and parasitic diseases or diseases produced by viruses and fungi in animals, including human beings; as well as to a method for preparing the compounds of the invention and certain intermediates of said method.
Type: Grant
Filed: January 11, 2005
Date of Patent: August 24, 2010
Assignees: Consejo Superior de Investigaciones Cientificas, Universidad de Granada
Inventors: Juan Carlos Lacal Sanjuán, Joaquin Campos Rosa, Miguel Ángel Gallo Mezo, Antonio Espinosa Úbeda
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Method for Identifying Compounds for Cancer Therapy
Publication number: 20110269948
Abstract: The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression.
Type: Application
Filed: May 2, 2011
Publication date: November 3, 2011
Applicant: Consejo Superior De Investigaciones Cientificas
Inventors: Juan Carlos Lacal Sanjuan, Ana Ramirez De Molina, David Gallego Ortega, Mónica Bañez Coronel
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METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Publication number: 20110256241
Abstract: The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and a chemotherapeutic agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and a death receptor ligand and uses thereof for the treatment of cancer.
Type: Application
Filed: September 17, 2009
Publication date: October 20, 2011
Applicant: TRASLATIONAL CANCER DRUGS PHARMA, S.L.
Inventors: Ana Ramirez De Molina, Lourdes Garcia Oroz, Juan Carlos Lacal Sanjuan
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IN VITRO METHOD FOR IDENTIFYING COMPOUNDS FOR CANCER THERAPY
Publication number: 20140023657
Abstract: The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression.
Type: Application
Filed: June 6, 2013
Publication date: January 23, 2014
Inventors: Juan Carlos LACAL SANJUAN, Ana RAMIREZ DE MOLINA, David GALLEGO ORTEGA, Monica Banez Coronel
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METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Publication number: 20100068302
Abstract: The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent or a death receptor ligand and uses thereof for the treatment of cancer.
Type: Application
Filed: December 8, 2008
Publication date: March 18, 2010
Applicant: TRASLATIONAL CANCER DRUGS PHARMA, S.L.
Inventors: Ana Ramirez De Molina, Lourdes Garcia Oroz, Juan Carlos Lacal Sanjuan
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Method for identifying compounds for cancer therapy
Patent number: 8901096
Abstract: The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression.
Type: Grant
Filed: May 2, 2011
Date of Patent: December 2, 2014
Assignee: Consejo Superior de Investigaciones Cientificas
Inventors: Juan Carlos Lacal Sanjuan, Ana Ramirez de Molina, David Gallego Ortega, Mónica Bañez Coronel
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METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER
Publication number: 20110250179
Abstract: The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoK?) activity as well as to methods for the design of personalized therapies and for determining the response of an agent capable of inducing choline kinase beta (hereinafter ChoK?) for the treatment of cancer as well as to methods for determining the prognosis of a patient based on the determination of the ChoK? expression levels as well as based on the determination of the relationship between the ChoK? and ChoK? expression levels. Finally, the invention relates to methods for determining the response of a patient who suffers from cancer to ChoK?-inhibiting agents based on the determination of the PEMT and/or ChoK? expression levels.
Type: Application
Filed: July 6, 2009
Publication date: October 13, 2011
Inventors: Juan Carlos Lacal Sanjuan, Ana Ramirez De Molina, David Gallego Ortega
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In vitro method for identifying compounds for cancer therapy
Patent number: 8481256
Abstract: The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression.
Type: Grant
Filed: April 12, 2006
Date of Patent: July 9, 2013
Assignee: Consejo Superior de Investigaciones Cientificas
Inventors: Juan Carlos Lacal Sanjuan, Ana Ramirez de Molina, David Gallego Ortega, Mónica Bañez Coronel
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METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER
Publication number: 20150098927
Abstract: The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoK?) activity as well as to methods for the design of personalized therapies and for determining the response of an agent capable of inducing choline kinase beta (hereinafter ChoK?) for the treatment of cancer as well as to methods for determining the prognosis of a patient based on the determination of the ChoK? expression levels as well as based on the determination of the relationship between the ChoK? and ChoK? expression levels. Finally, the invention relates to methods for determining the response of a patient who suffers from cancer to ChoK?-inhibiting agents based on the determination of the PEMT and/or ChoK? expression levels.
Type: Application
Filed: October 8, 2014
Publication date: April 9, 2015
Applicant: TRASLATIONAL CANCER DRUGS PHARMA, S.L.
Inventors: Juan Carlos Lacal SanJuan, Ana Ramirez De Molina, David Gallego Ortega
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IN VITRO METHOD FOR IDENTIFYING COMPOUNDS FOR CANCER THERAPY
Publication number: 20090304575
Abstract: The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression.
Type: Application
Filed: April 12, 2006
Publication date: December 10, 2009
Applicant: Consejo Superior De Investigaciones Cientificas
Inventors: Juan Carlos Lacal Sanjuan, Ana Ramirez de Molina, David Gallego Ortega, Mónica Bañez Coronel
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METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Publication number: 20120040021
Abstract: The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent or a death receptor ligand and uses thereof for the treatment of cancer.
Type: Application
Filed: August 12, 2011
Publication date: February 16, 2012
Applicant: TRASLATIONAL CANCER DRUGS PHARMA, S.L.
Inventors: Ana Ramirez De Molina, Lourdes Garcia Oroz, Juan Carlos Lacal Sanjuan
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METHOD FOR PREDICTING THE CLINICAL RESPONSE TO CHEMOTHERAPY IN A SUBJECT WITH CANCER
Publication number: 20150004252
Abstract: The invention relates to the use of choline kinase alpha as predictive marker for the determination of the response to a chemotherapeutic treatment in a subject suffering from cancer, particularly for predicting the clinical response of a subject suffering from non-small cell lung cancer to a platinum-based chemotherapeutic treatment. The invention relates to methods for designing a personalised therapy for subjects suffering from cancer, particularly from non-small cell lung cancer, based on the expression levels of choline kinase alpha as well as to methods for the treatment of non-small cell lung cancer using a platinum-based chemotherapeutic treatment based in a subject wherein the subject is selected based on the expression levels of choline kinase alpha.
Type: Application
Filed: June 20, 2012
Publication date: January 1, 2015
Applicant: TRASLATIONAL CANCER DRUGS PHARMA, S.L
Inventor: Juan Carlos Lacal SanJuan
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Method and Apparatus for UE Reachability Event Enhancements
Publication number: 20240121594
Abstract: A method implemented by a first network node in a communication network is provided. The method comprises: receiving a first subscription for subscribing a first User Equipment UE reachability event of a UE from an event subscriber, wherein the first subscription comprises a first indicator for indicating whether the first UE reachability event is to be reported in a direct mode or an indirect mode; sending a second subscription for subscribing a second UE reachability event to a second network node that is registered in the first network node, the second subscription comprises a second indicator for indicating that the first UE reachability event is to be directly or indirectly reported to the event subscriber according to the first indicator; and sending a first UE reachability report to the event subscriber.
Type: Application
Filed: January 25, 2022
Publication date: April 11, 2024
Inventors: Emiliano Merino Vazquez, Cheng Wang, Jose Miguel Dopico Sanjuan, Yunjie Lu, Juan Manuel Fernandez Galmes
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PRINT BAR FOR A MULTI-PASS PRINTER AND MULT-PASS PAGE-WIDE-ARRAY PRINTER
Publication number: 20190291484
Abstract: A print bar for a for a multi-pass printer, the print bar comprising a static part configured to extend across a print area of a print target and a moveable part comprising a print bar beam and printer comprising such a print bar.
Type: Application
Filed: April 4, 2019
Publication date: September 26, 2019
Inventors: Joan Sanjuan, Fernando Juan, Eduardo Ruiz Martinez
